报告题目：Microbiota, microbes and human health: A closer look at the Lactobacillus rhamnosus species
报告人：Dr. Francois Douillard
François Douillard博士，芬兰赫尔辛基大学食品卫生与环境健康系，博士后。研究方向为致病菌和肠道微生物功能基因组学及转录组学、宿主-细菌相互作用、肠道细菌生态学及进化。在Nature Communications, Journal of Biological Chemistry, Applied Environmental Microbiology等期刊上发表学术论文28篇，是25个SCI期刊的审稿人。在加入Miia Lindström教授团队之前，他曾在欧洲不同研究机构工作，在Willem de Vos、Douwe van Sinderen、Paul O’Toole教授的团队参与多个国际项目的研究。
Since early life, we are colonized by developing microbial communities that are associated with human health and diseases. Until recently, the intestinal microbiota was poorly comprehended. However, the development of high throughput molecular analytic tools changed our way to approach the complexity of this unique and remarkable ecosystem and we are now at the dawn of major findings on its inhabitants and their intricate relationships with the human host. Over the last years, our research work focused on investigating metabolic properties and colonization factors present in gut lactobacilli, from an evolutionary and ecological perspective. We examined the Lactobacillus rhamnosus species and more specifically the paradigm probiotic strain Lactobacillus rhamnosus GG that is known to be piliated and to be able to signal to human host cells. Our research aimed at bringing insights in how some of our gut microbes develop mutualistic interactions with the host, allowing for the design of new food-based approaches and the development of novel functional food products.